Proteomic dementia risk assessment in hypertension
Yuye Ning, Zhibo Wang, Meilin Chen, Jianping Jia · 2025
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Description
Yuye Ning and co-authors ask whether a blood protein fingerprint can forecast dementia in people with high blood pressure. Hypertension alone raises dementia risk, and plasma proteomics now measures about three thousand proteins at once. From the UK Biobank, the team followed over fourteen thousand hypertensive adults with no dementia for a median of about fourteen years, during which five hundred seventy-five developed it.
A selection algorithm distilled sixty-one proteins into a risk model. That model predicted dementia clearly better than one built from age, sex, education, and the APOE gene, and far better than a cognitive test model. Combining all three edged slightly higher still, and the protein model was well calibrated. The authors propose proteomics as a sharper triage tool for hypertensive patients.
Catalog record
| CREATOR | Yuye Ning, Zhibo Wang, Meilin Chen, Jianping Jia |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |