Intracellular adhesion molecule 1 in prodromal Alzheimer’s disease
Qumars Behfar, Stefan Kambiz Behfar, Oezguer A Onur · 2025
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Description
Qumars Behfar, Stefan Behfar, and Oezguer Onur studied a cell adhesion molecule in 2025 as a marker in the early, prodromal phase of Alzheimer disease. Age is the strongest risk factor for the disease, yet not all older people move toward dementia. Aging involves cell senescence, where worn cells release immune signals that keep low-grade inflammation simmering.
The team asked whether spinal fluid levels of proteins from that secretory pattern track faster biological aging, and whether that speed affects progress along the Alzheimer path. Biological age was computed from blood DNA methylation with known epigenetic clocks, in a large imaging initiative cohort. The named molecule is framed as a candidate signal in spinal fluid. Readers get a look at how the biology of aging itself, not just plaques, may mark early Alzheimer risk.
Catalog record
| CREATOR | Qumars Behfar, Stefan Kambiz Behfar, Oezguer A Onur |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |