Obstructive sleep apnea severity is associated with CSF biomarkers of synaptic dysfunction and neuroinflammation in a cohort at risk for AD
Kyle J Edmunds, Brianne M Breidenbach, Matthew P Glittenberg, Sterling C Johnson, Sanjay Asthana, Catherine L Gallagher, Bruce P Hermann, Mark A Sager, Cynthia M Carlsson, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Kaj Blennow, Henrik Zetterberg, Barbara B Bendlin, Paul E Peppard, Ozioma C Okonkwo · 2025
Read Obstructive sleep apnea severity is associated with CSF biomarkers of synaptic dysfunction and neuroinflammation in a cohort at risk for AD by Kyle J Edmunds, Brianne M Breidenbach, Matthew P Glittenberg, Sterling C Johnson, Sanjay Asthana, Catherine L Gallagher, Bruce P Hermann, Mark A Sager, Cynthia M Carlsson, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Kaj Blennow, Henrik Zetterberg, Barbara B Bendlin, Paul E Peppard, Ozioma C Okonkwo (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716130.txt.
Description
Kyle Edmunds and co-authors link sleep apnea severity with spinal fluid markers of brain harm in a 2025 paper. Apnea interrupts breathing during sleep and starves the brain of oxygen in short bursts. That strain may feed the changes behind Alzheimer's disease. The team studied adults who were thinking normally but carried a raised risk of the disease.
Twenty-five adults from a Wisconsin research center took part in an overnight sleep study. Staff counted their breathing pauses and broken breathing events per hour of sleep. Spinal fluid was drawn at two later visits, about six years apart on average. The fluid panel covered Alzheimer's proteins plus markers of synapse damage and brain inflammation, letting the team track how apnea severity lined up with each marker over time.
Catalog record
| CREATOR | Kyle J Edmunds, Brianne M Breidenbach, Matthew P Glittenberg, Sterling C Johnson, Sanjay Asthana, Catherine L Gallagher, Bruce P Hermann, Mark A Sager, Cynthia M Carlsson, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Kaj Blennow, Henrik Zetterberg, Barbara B Bendlin, Paul E Peppard, Ozioma C Okonkwo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |