BOLD fMRI signal changes in preclinical Alzheimer’s disease
Stanislau Hrybouski, Sandhitsu R Das, Long Xie, Xueying Lyu, Laura EM Wisse, Melissa Kelley, Jacqueline Lane, Monica Sherin, Michael DiCalogero, Ilya M Nasrallah, John A Detre, Paul A Yushkevich, David A Wolk · 2025
Read BOLD fMRI signal changes in preclinical Alzheimer’s disease by Stanislau Hrybouski, Sandhitsu R Das, Long Xie, Xueying Lyu, Laura EM Wisse, Melissa Kelley, Jacqueline Lane, Monica Sherin, Michael DiCalogero, Ilya M Nasrallah, John A Detre, Paul A Yushkevich, David A Wolk (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716088.txt.
Description
Stanislau Hrybouski and co-authors look for early brain activity changes in people who carry Alzheimer's changes but feel no symptoms, in a 2025 paper. Resting brain scans record a signal that rises and falls with blood flow. The strength of its slow waves may shift as disease proteins gather. The team focused on the memory regions of the inner temporal lobe, among the first places the disease strikes.
The study drew on 224 people from a University of Pennsylvania cohort. Everyone had structural and resting scans, plus an amyloid scan; 125 also had a tau scan. The authors measured the slow-wave signal strength across the whole brain and in fine detail within the memory regions. Comparing those readings with protein load shows whether quiet brain activity changes before memory fails, which could offer an early warning sign.
Catalog record
| CREATOR | Stanislau Hrybouski, Sandhitsu R Das, Long Xie, Xueying Lyu, Laura EM Wisse, Melissa Kelley, Jacqueline Lane, Monica Sherin, Michael DiCalogero, Ilya M Nasrallah, John A Detre, Paul A Yushkevich, David A Wolk |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |