Plasma N‐terminal tau fragment is associated with cognitive status and AD biomarkers of tau and neurodegeneration in older adults
Yiwen Rao, Beth L Ostaszewski, Amirah K Anderson, Zahra Shirzadi, Lei Liu, Hyun‐Sik Yang, Jasmeer P Chhatwal, Dennis J Selkoe, Stephanie A Schultz, ADNI · 2025
Read Plasma N‐terminal tau fragment is associated with cognitive status and AD biomarkers of tau and neurodegeneration in older adults by Yiwen Rao, Beth L Ostaszewski, Amirah K Anderson, Zahra Shirzadi, Lei Liu, Hyun‐Sik Yang, Jasmeer P Chhatwal, Dennis J Selkoe, Stephanie A Schultz, ADNI (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716087.txt.
Description
Yiwen Rao and co-authors test a blood tau fragment as a marker of Alzheimer-related brain changes in older adults. Blood markers promise cheaper, gentler screening than scans or spinal taps. The N-terminal tau fragment may rise earlier than full tau.
The cohort came from a large Alzheimer imaging initiative. Hundreds of volunteers had blood, brain scan, and rating data. The fragment levels were compared across thinking status groups. Levels tracked with tau and shrinkage markers on scans. Prior work showed it separates healthy adults from impaired ones. This study extends that check to a bigger, rich cohort. Cross-sectional links support its screening promise. Longer follow-up could prove its forecast value.
Catalog record
| CREATOR | Yiwen Rao, Beth L Ostaszewski, Amirah K Anderson, Zahra Shirzadi, Lei Liu, Hyun‐Sik Yang, Jasmeer P Chhatwal, Dennis J Selkoe, Stephanie A Schultz, ADNI |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |