In‐vivo plasma biomarker concentrations correlate with postmortem AD‐neuropathology in the oldest old
Linda MC Lorenz, Susan K Rohde, Maruelle C Luimes, Patricia Fierro‐Hernández, Annemieke JM Rozemuller, Netherlands Brain Bank, Jeroen JM Hoozemans, Charlotte Teunissen, Henne Holstege · 2025
Read In‐vivo plasma biomarker concentrations correlate with postmortem AD‐neuropathology in the oldest old by Linda MC Lorenz, Susan K Rohde, Maruelle C Luimes, Patricia Fierro‐Hernández, Annemieke JM Rozemuller, Netherlands Brain Bank, Jeroen JM Hoozemans, Charlotte Teunissen, Henne Holstege (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716064.txt.
Description
Linda Lorenz and colleagues test whether blood biomarkers read during life match the Alzheimer's pathology found after death in the oldest old. Brains of the very old often hold mixed amyloid and tau loads, so the match was in doubt. Forty-eight centenarian brains from self-reported healthy donors were checked, with blood drawn a median of 1.3 years before donation.
One marker, plasma pTau-181, tracked both amyloid load and tau load in the cortex, and the amyloid spread stage as well. It did not track the tau spread stage. The study supports blood pTau-181 as a fair stand-in for cortical Alzheimer's pathology even past age one hundred.
Catalog record
| CREATOR | Linda MC Lorenz, Susan K Rohde, Maruelle C Luimes, Patricia Fierro‐Hernández, Annemieke JM Rozemuller, Netherlands Brain Bank, Jeroen JM Hoozemans, Charlotte Teunissen, Henne Holstege |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |