Psoriasis and dementia: a population‐based matched cohort study of adults in England
Julian Matthewman, Sharon L Cadogan, Katrina Abuabara, Krishnan Bhaskaran, Catherine Smith, Kathryn E Mansfield, Sinéad Langan, Charlotte Warren‐Gash · 2025
Read Psoriasis and dementia: a population‐based matched cohort study of adults in England by Julian Matthewman, Sharon L Cadogan, Katrina Abuabara, Krishnan Bhaskaran, Catherine Smith, Kathryn E Mansfield, Sinéad Langan, Charlotte Warren‐Gash (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716057.txt.
Description
Julian Matthewman and co-authors weigh whether the skin disease psoriasis raises the risk of dementia, in a 2025 study of adults in England. Psoriasis involves long-term inflammation, and inflammation has been linked to Alzheimer's disease. Earlier work on the question was thin and mixed. The team also asked whether worse skin disease means higher risk.
The researchers used primary care records and hospital data covering 1997 to 2022. They matched 360,014 people with psoriasis to about 1.8 million people without it, by age, sex, and practice. People with psoriasis had a slightly higher rate of dementia overall, about four extra cases per 10,000 person years. The link held for vascular dementia but not for Alzheimer's disease. The authors stress that the absolute difference was small.
Catalog record
| CREATOR | Julian Matthewman, Sharon L Cadogan, Katrina Abuabara, Krishnan Bhaskaran, Catherine Smith, Kathryn E Mansfield, Sinéad Langan, Charlotte Warren‐Gash |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |