Alpha Synuclein co‐pathology is associated with faster Ab‐related tau accumulation in Alzheimer’s disease
Sebastian Niclas Roemer, Amir Dehsarvi, Anna Steward, Anna Dewenter, Julia Pescoller, Fabian Wagner, Johannes Levin, Matthias Brendel, Günter Höglinger, Nicolai Franzmeier · 2025
Read Alpha Synuclein co‐pathology is associated with faster Ab‐related tau accumulation in Alzheimer’s disease by Sebastian Niclas Roemer, Amir Dehsarvi, Anna Steward, Anna Dewenter, Julia Pescoller, Fabian Wagner, Johannes Levin, Matthias Brendel, Günter Höglinger, Nicolai Franzmeier (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716050.txt.
Description
Sebastian Roemer and co-authors test whether a second brain protein speeds Alzheimer's damage in a 2025 study. Clumps of alpha-synuclein, the Parkinson's hallmark, often appear beside Alzheimer's plaques. Lab work says the clumps can boost tau tangles driven by amyloid.
The team combined spinal fluid tests for the protein with brain scans in over five hundred people, from healthy to demented. The protein's seeds showed up more as illness advanced. They were far more common in amyloid-positive people, nearing half of the demented group. A subset had repeat tau scans over about two and a half years. The analysis asked whether seed-positive brains piled up tau faster.
Catalog record
| CREATOR | Sebastian Niclas Roemer, Amir Dehsarvi, Anna Steward, Anna Dewenter, Julia Pescoller, Fabian Wagner, Johannes Levin, Matthias Brendel, Günter Höglinger, Nicolai Franzmeier |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |