Widespread neurite degeneration in mild cognitive impairment and Alzheimer's disease revealed using advanced diffusion MRI
John P Laporte, Zhaoyuan Gong, Alex Guo, Jonghyun Bae, Mary E Faulkner, Mustapha Bouhrara · 2025
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Description
John Laporte and five co-authors scan for dying nerve fibers in mild memory loss and Alzheimer's disease using an improved imaging method. The method estimates neurite density, the thickness of the wiring in each brain spot, from diffusion scans. An earlier technique sometimes returned implausible values, even suggesting growth where loss was expected. The team's constrained version fixed those readings. They applied both methods to scans from a major Alzheimer's study.
The patient groups showed clearly lower density than healthy controls across wide brain areas. The constrained method spotted the subtler gaps too, between healthy and mildly impaired people and between mild impairment and full disease, where the older method missed or reversed them. Only the improved density scores tracked thinking-test results in the expected direction. The authors propose the measure as a sharper trial biomarker.
Catalog record
| CREATOR | John P Laporte, Zhaoyuan Gong, Alex Guo, Jonghyun Bae, Mary E Faulkner, Mustapha Bouhrara |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |