The association between grey matter microstructural MRI biomarkers, mid‐life blood pressure, and late‐life Alzheimer’s disease pathology
Philip SJ Weston, William Coath, Thomas M. Brown, Catherine J Scott, Ian B. Malone, Erik Arstad, Ramla Awais, Kerstin Sander, David L Thomas, John C Dickson, Michael Schöll, Marcus Richards, Nick C Fox, Hui Zhang, David M Cash, Jonathan M Schott · 2025
Read The association between grey matter microstructural MRI biomarkers, mid‐life blood pressure, and late‐life Alzheimer’s disease pathology by Philip SJ Weston, William Coath, Thomas M. Brown, Catherine J Scott, Ian B. Malone, Erik Arstad, Ramla Awais, Kerstin Sander, David L Thomas, John C Dickson, Michael Schöll, Marcus Richards, Nick C Fox, Hui Zhang, David M Cash, Jonathan M Schott (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716048.txt.
Description
Philip SJ Weston and co-authors study fine brain structure in members of the British 1946 birth cohort, in this 2025 paper. All were born in the same week and have given health data across their lives, including blood pressure readings from age forty-three on. At about age seventy-three to seventy-six they received brain scans plus tracer scans for Alzheimer's proteins.
The team used a scan measure of how complex the tiny branches of nerve cells are. That measure was lower in people who carried both amyloid and tau than in other groups. A simpler scan measure instead tracked with blood pressure from midlife onward. The split suggests the two scan types pick up different kinds of damage: one for disease proteins, one for blood vessel wear.
Catalog record
| CREATOR | Philip SJ Weston, William Coath, Thomas M. Brown, Catherine J Scott, Ian B. Malone, Erik Arstad, Ramla Awais, Kerstin Sander, David L Thomas, John C Dickson, Michael Schöll, Marcus Richards, Nick C Fox, Hui Zhang, David M Cash, Jonathan M Schott |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |