Association between the social exposome and vascular brain injury in brain bank donors
Sarah A Keller, W Ryan Powell, William R Buckingham, Amanda DeWitt, Barbara B Bendlin, Amy JH Kind · 2025
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Description
Sarah Keller and co-authors link a lifetime of social hardship to vessel damage in the brain. Their 2025 study uses 740 donors from two brain banks. Life-course addresses were matched to a county hardship index for the years each donor lived there.
More years spent in harder-than-median counties went with more vessel injury at death. Donors whose hardship rose from youth to adulthood, or stayed high, had roughly triple the odds of injury. Injury was judged by strokes, small strokes, bleeds, and white matter loss. The authors argue that timing and dose of hardship matter for dementia risk. Cutting hardship could be one lever against unequal brain ageing.
Catalog record
| CREATOR | Sarah A Keller, W Ryan Powell, William R Buckingham, Amanda DeWitt, Barbara B Bendlin, Amy JH Kind |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |