Single‐cell transcriptomic landscapes of neurodegenerative diseases: towards mapping shared and distinct mechanisms
Elliot Keats Shwab, Zhaohui Man, Daniel Gingerich, Melanie E Garrett, Gregory Crawford, Allison Ashley‐Koch, Ornit Chiba‐Falek · 2025
Read Single‐cell transcriptomic landscapes of neurodegenerative diseases: towards mapping shared and distinct mechanisms by Elliot Keats Shwab, Zhaohui Man, Daniel Gingerich, Melanie E Garrett, Gregory Crawford, Allison Ashley‐Koch, Ornit Chiba‐Falek (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715989.txt.
Description
Elliot Shwab and co-authors map single cell gene activity across three neurodegenerative diseases in a 2025 study. Late onset Alzheimer disease, dementia with Lewy bodies, and Parkinson disease share some traits and differ in others. Each has a complex genetic base, and many risk loci are known, yet the causal genes and the exact cell subtypes they act through remain unclear.
Single nucleus profiling was done on brains from patients with each disease and from normal controls, in equal sized groups. Changed genes were compared across diseases within each cell type to find shared and distinct pathways. Statistical models then identified the vulnerable, disease driving cell subtypes for each condition.
Catalog record
| CREATOR | Elliot Keats Shwab, Zhaohui Man, Daniel Gingerich, Melanie E Garrett, Gregory Crawford, Allison Ashley‐Koch, Ornit Chiba‐Falek |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |