Varicella zoster and the risk of dementia: understanding the interplay between age, the genome and proteome
Najaf Amin, M Austin Argentieri, Sihao Xiao, Cornelia M Van Duijn · 2025
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Description
The chickenpox virus, varicella zoster, stays in the body for life, and researchers suspect it may play a role in Alzheimer's disease. Najaf Amin, Austin Argentieri, Sihao Xiao, and Cornelia Van Duijn tested one link in 2025 in the UK Biobank: a blood protein called PVR that several viruses use to enter cells. Data covered fifty-three thousand people, of whom 592 developed Alzheimer's over thirteen years.
PVR was among thirty-seven blood proteins tied to later Alzheimer's, and genetic analysis suggested the link may be causal. PVR also tracked with two early brain markers, with faster body aging, and with having antibodies to the chickenpox virus. The link held after accounting for the well-known APOE gene nearby.
Catalog record
| CREATOR | Najaf Amin, M Austin Argentieri, Sihao Xiao, Cornelia M Van Duijn |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |