Using fixel‐based analysis to understand the role of crossing fibers in age‐related white matter decline
Aditi Sathe, Niranjana Shashikumar, Elizabeth E. Moore, Kimberly R. Pechman, Kurt Schilling, Bennett A. Landman, Katherine A. Gifford, Andrew R. Bender, Timothy J. Hohman, Angela L. Jefferson, Derek B. Archer · 2025
Read Using fixel‐based analysis to understand the role of crossing fibers in age‐related white matter decline by Aditi Sathe, Niranjana Shashikumar, Elizabeth E. Moore, Kimberly R. Pechman, Kurt Schilling, Bennett A. Landman, Katherine A. Gifford, Andrew R. Bender, Timothy J. Hohman, Angela L. Jefferson, Derek B. Archer (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715966.txt.
Description
Aditi Sathe and co-authors use fixel-based analysis to study age-related white matter decline, in this 2025 Europe PMC paper. Standard diffusion imaging blurs detail where nerve fibers cross. Fixel-based analysis gives sharper measures in those crossing zones. Data came from a Vanderbilt cohort of more than three hundred older adults, forty percent with mild cognitive impairment.
The team computed fiber density, bundle cross-section and a combined measure, split by how many fiber bundles meet in each region. All three measures fell with age, with the main fiber bundle in each spot showing the largest drop. The approach clarifies how aging affects distinct fiber populations that older methods merge together.
Catalog record
| CREATOR | Aditi Sathe, Niranjana Shashikumar, Elizabeth E. Moore, Kimberly R. Pechman, Kurt Schilling, Bennett A. Landman, Katherine A. Gifford, Andrew R. Bender, Timothy J. Hohman, Angela L. Jefferson, Derek B. Archer |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |