Biological aging is associated with atypical neurodegenerative patterns in Alzheimer’s disease
Lasya P Sreepada, Christopher Brown, Sandhitsu R. Das, Paul A. Yushkevich, David A Wolk, Corey T McMillan · 2025
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Description
Lasya P Sreepada and five co-authors ask whether how old a person's body seems, measured from chemical marks on DNA, predicts unusual patterns of Alzheimer's damage, in this 2025 study. Odd presentations of the disease, with more damage in outer brain regions than in memory centers, usually start younger. The team wondered if biological age explains the pattern better than age in years.
Data came from 646 people in a national study who gave blood samples and brain scans. The authors computed an epigenetic age from the blood and flagged people aging faster or slower than their years. Patients with memory problems or disease showed thinner cortex than controls. Early results link faster biological aging with the atypical damage pattern. The work may help explain why the disease looks different in different people.
Catalog record
| CREATOR | Lasya P Sreepada, Christopher Brown, Sandhitsu R. Das, Paul A. Yushkevich, David A Wolk, Corey T McMillan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |