A systematic review and meta‐analysis of the association between mood disorders and Alzheimer’s dementia
Liwei Ma, Benjamin Goudey, Colin L Masters, Liang Jin, Yijun Pan · 2025
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Description
Ma and co-authors present a 2025 review pooling cohort studies on mood disorders and later dementia. Anxiety and depression can surface decades before memory fails. Four databases were searched for long-run studies tying the two to mild impairment or Alzheimer's disease. Thirty-nine studies qualified, and pooled risk ratios were built with a random-effects model.
Anxiety raised the odds of mild impairment by about half but showed no firm link to Alzheimer's itself. Depression raised both: impairment by about a third, Alzheimer's by well over half. Evidence grades were scored with a standard tool. The authors urge doctors to treat midlife mood as a brain-health signal, not a side note.
Catalog record
| CREATOR | Liwei Ma, Benjamin Goudey, Colin L Masters, Liang Jin, Yijun Pan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |