Association between hippocampal subfield volume estimated from ultra‐high field scans and cognitive and clinical symptoms in patients with late‐life depression and healthy controls
Xiaochen Hu, Philip Zeyen, Gérard N Bischof, David Elmenhorst, Gregory Andrassy, Beyza Aktas, Neele Schruttke, You Na Lee, Niloofar Mokhtari, David Berron, Kathrin Giehl, Oezguer A. Onur, Rüdiger Stirnberg, Thilo van Eimeren, Alexander Drzezga, Forugh S Dafsari, Tony Stoecker, Frank Jessen · 2025
Read Association between hippocampal subfield volume estimated from ultra‐high field scans and cognitive and clinical symptoms in patients with late‐life depression and healthy controls by Xiaochen Hu, Philip Zeyen, Gérard N Bischof, David Elmenhorst, Gregory Andrassy, Beyza Aktas, Neele Schruttke, You Na Lee, Niloofar Mokhtari, David Berron, Kathrin Giehl, Oezguer A. Onur, Rüdiger Stirnberg, Thilo van Eimeren, Alexander Drzezga, Forugh S Dafsari, Tony Stoecker, Frank Jessen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715942.txt.
Description
Xiaochen Hu and co-authors use ultra high field scans to inspect small parts of the hippocampus in older adults with depression, in this 2025 study. Depression late in life raises the risk of Alzheimer's disease, and past scans at standard strength gave mixed results on which memory subregions shrink. A stronger 7-Tesla scanner gives a sharper view.
Ninety-three people over sixty entered the study, and a subset of patients and controls received the high field scans. Total hippocampus size did not differ between the groups. One small part, the front section of a region called the dentate gyrus, was smaller on the right side in patients. Whole hippocampus size also tracked with test speed and anxiety scores. The authors see the changes as subtle rather than sweeping.
Catalog record
| CREATOR | Xiaochen Hu, Philip Zeyen, Gérard N Bischof, David Elmenhorst, Gregory Andrassy, Beyza Aktas, Neele Schruttke, You Na Lee, Niloofar Mokhtari, David Berron, Kathrin Giehl, Oezguer A. Onur, Rüdiger Stirnberg, Thilo van Eimeren, Alexander Drzezga, Forugh S Dafsari, Tony Stoecker, Frank Jessen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |