Adult lifespan neurodegeneration is associated with memory decline independent of amyloid deposition
James M Roe, William J Jagust, Susan M Landau, Theresa M Harrison, Håkon Grydeland, Maksim Slivka, José‐Luis Alatorre‐Warren, Øystein Sørensen, Kristine B Walhovd, Anders M Fjell, Didac Vidal‐Piñeiro, Yunpeng Wang · 2025
Read Adult lifespan neurodegeneration is associated with memory decline independent of amyloid deposition by James M Roe, William J Jagust, Susan M Landau, Theresa M Harrison, Håkon Grydeland, Maksim Slivka, José‐Luis Alatorre‐Warren, Øystein Sørensen, Kristine B Walhovd, Anders M Fjell, Didac Vidal‐Piñeiro, Yunpeng Wang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715913.txt.
Description
James M Roe and co-authors ask whether the slow brain shrinkage of normal adult aging predicts memory decline on its own, apart from Alzheimer's disease, in this 2025 study. Standard models place shrinkage late in a chain that starts with amyloid buildup. Yet the brain regions hit hardest by the disease are also the ones that shrink fastest across a healthy life.
The team pooled repeat scans from three large cohorts, over four thousand scans from about a thousand healthy adults aged thirty to ninety-six. Change in brain structure tracked with change in memory across adulthood. In a smaller group with amyloid scans, the link held even without amyloid present. The results suggest some memory loss in aging follows plain brain change, not hidden disease.
Catalog record
| CREATOR | James M Roe, William J Jagust, Susan M Landau, Theresa M Harrison, Håkon Grydeland, Maksim Slivka, José‐Luis Alatorre‐Warren, Øystein Sørensen, Kristine B Walhovd, Anders M Fjell, Didac Vidal‐Piñeiro, Yunpeng Wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |