High cognitive reserve postpones dementia onset in older adults with cardiometabolic disease
Abigail Dove, Wenzhe Yang, Serhiy Dekhtyar, Jie Guo, Jiao Wang, Anna Marseglia, Davide Liborio Vetrano, Rachel A Whitmer, Weili Xu · 2025
Read High cognitive reserve postpones dementia onset in older adults with cardiometabolic disease by Abigail Dove, Wenzhe Yang, Serhiy Dekhtyar, Jie Guo, Jiao Wang, Anna Marseglia, Davide Liborio Vetrano, Rachel A Whitmer, Weili Xu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715911.txt.
Description
Dove and co-authors ask whether a strong store of mental resources can delay dementia in people with heart and metabolic disease. Their 2025 study follows more than 216,000 dementia-free adults aged 60 and over in the UK Biobank for up to 15 years. That store, called cognitive reserve, was scored from schooling, work, social contact, and leisure habits.
People with diabetes, heart disease, or stroke faced a much higher risk of dementia overall. Among them, those with a moderate or high reserve score had notably lower risk than those with a low score. Brain scans in a smaller group also showed less tissue loss in the high reserve group. The authors say reserve seems to blunt part of the harm from these diseases.
Catalog record
| CREATOR | Abigail Dove, Wenzhe Yang, Serhiy Dekhtyar, Jie Guo, Jiao Wang, Anna Marseglia, Davide Liborio Vetrano, Rachel A Whitmer, Weili Xu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |