Multivariate Neuroimaging Analyses Reveal an Important Role for Iron Metabolism in Populations at Risk for Alzheimer’s Disease
Alexandra Badea, Hae Sol Moon, Robert J Anderson, Ali Mahzarnia, Jacques Andrew Stout, Zay Yar Han, Kim G Johnson, Richard J O'Brien · 2025
Read Multivariate Neuroimaging Analyses Reveal an Important Role for Iron Metabolism in Populations at Risk for Alzheimer’s Disease by Alexandra Badea, Hae Sol Moon, Robert J Anderson, Ali Mahzarnia, Jacques Andrew Stout, Zay Yar Han, Kim G Johnson, Richard J O'Brien (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715896.txt.
Description
Alexandra Badea and seven co-authors use several kinds of brain scan at once to study carriers of the APOE4 gene variant, in this 2025 study. That variant is a known risk factor for Alzheimer's disease. One scan type maps iron in the brain, which matters because iron handling goes wrong in the disease. Combining scan types can reveal changes a single method would miss.
The study covered ninety adults from age twenty to eighty-three, split between carriers and non-carriers. Age related changes ran stronger in carriers in vision and control regions. Iron based maps added memory regions such as the hippocampus to the picture. Combined analysis confirmed iron's role across several areas. The authors argue that iron metabolism deserves a central place in risk research.
Catalog record
| CREATOR | Alexandra Badea, Hae Sol Moon, Robert J Anderson, Ali Mahzarnia, Jacques Andrew Stout, Zay Yar Han, Kim G Johnson, Richard J O'Brien |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |