Investigation of blood‐brain barrier water exchange rate as a novel early indicator of neurovascular dysfunction and Alzheimer’s disease
Ella Rowsthorn, Ming Ann Sim, William O'Brien, Stuart McDonald, Lucy Vivash, Terence J O'Brien, Meng Law, Trevor T‐J Chong, Xingfeng Shao, Danny JJ Wang, Matthew P Pase, Ian H Harding · 2025
Read Investigation of blood‐brain barrier water exchange rate as a novel early indicator of neurovascular dysfunction and Alzheimer’s disease by Ella Rowsthorn, Ming Ann Sim, William O'Brien, Stuart McDonald, Lucy Vivash, Terence J O'Brien, Meng Law, Trevor T‐J Chong, Xingfeng Shao, Danny JJ Wang, Matthew P Pase, Ian H Harding (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715890.txt.
Description
Ella Rowsthorn and co-authors test a new MRI measure of the blood-brain barrier's water traffic as an early signal of Alzheimer's disease, in a 2025 study. The barrier's plumbing falters early in the disease, possibly before memory does. The measure, called kw, rates how fast water crosses the barrier. Lower values have been tied to vascular risk, but links with age, brain vessel health, and Alzheimer's proteins were unclear.
The team scanned 108 dementia-free volunteers aged fifty-five to eighty. Alongside the water measure, they imaged swollen perivascular spaces and free water in tissue, and sampled spinal fluid for amyloid. Relating the measures shows whether barrier water traffic belongs in the early-warning panel. The authors frame the work as biomarker hunting: finding changes that arrive before symptoms makes prevention trials possible.
Catalog record
| CREATOR | Ella Rowsthorn, Ming Ann Sim, William O'Brien, Stuart McDonald, Lucy Vivash, Terence J O'Brien, Meng Law, Trevor T‐J Chong, Xingfeng Shao, Danny JJ Wang, Matthew P Pase, Ian H Harding |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |