Serum Soluble CD14 is Associated with Insulin Resistance and Cortical Inflammation in Nonhuman Primates Consuming Western versus Mediterranean Diets
Brett M. Frye, Jacob D. Negrey, Courtney L. Sutphen, Suzanne Craft, Carol A. Shively, Thomas C. Register · 2025
Read Serum Soluble CD14 is Associated with Insulin Resistance and Cortical Inflammation in Nonhuman Primates Consuming Western versus Mediterranean Diets by Brett M. Frye, Jacob D. Negrey, Courtney L. Sutphen, Suzanne Craft, Carol A. Shively, Thomas C. Register (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715882.txt.
Description
Brett M Frye and five co-authors compare two long term diets in monkeys to learn how food shapes inflammation in the body and brain, in this 2025 study. One group ate a Western style diet and the other a Mediterranean style diet for thirty-one months. The team tracked a blood marker of immune cell activity called sCD14, plus insulin responses and gene activity in the brain.
Monkeys on the Mediterranean diet showed lower levels of the immune marker than those on the Western diet. Higher marker levels went with worse insulin responses and with lower activity of brain genes tied to protection against inflammation. The pattern supports the idea that a Mediterranean diet calms body wide inflammation, which may in turn protect the aging brain.
Catalog record
| CREATOR | Brett M. Frye, Jacob D. Negrey, Courtney L. Sutphen, Suzanne Craft, Carol A. Shively, Thomas C. Register |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |