Generalizability of demographic and genetic variable interactions with amyloid driving tau burden in a heterogeneous group of cognitively normal older adults: A multi‐cohort study
Theresa M Harrison, Tyler J Ward, Trevor Chadwick, Jacinda Taggett, Suzanne L Baker, Meredith N Braskie, Susan M Landau, William J Jagust, the U.S. POINTER Study Group, the Alzheimer's Disease Neuroimaging Initiative · 2025
Read Generalizability of demographic and genetic variable interactions with amyloid driving tau burden in a heterogeneous group of cognitively normal older adults: A multi‐cohort study by Theresa M Harrison, Tyler J Ward, Trevor Chadwick, Jacinda Taggett, Suzanne L Baker, Meredith N Braskie, Susan M Landau, William J Jagust, the U.S. POINTER Study Group, the Alzheimer's Disease Neuroimaging Initiative (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715880.txt.
Description
Theresa Harrison and co-authors ask whether the rules linking amyloid to tau in the aging brain hold across the very different cohorts science now pools. Over twenty-one hundred cognitively normal older adults from four studies had amyloid and tau PET scans harmonized onto common scales, alongside sex, race and ethnicity, and APOE genotype.
In pooled models, women accumulated disproportionately more tau in the entorhinal cortex as amyloid rose, an interaction not seen in the wider temporal region. Non-Hispanic White participants gained more tau per unit of amyloid than Black participants. Carrying the APOE4 variant steepened the amyloid-to-tau slope as well. The authors argue these interactions mostly generalize, which is what makes pooling honest, but they must be modeled rather than averaged away.
Catalog record
| CREATOR | Theresa M Harrison, Tyler J Ward, Trevor Chadwick, Jacinda Taggett, Suzanne L Baker, Meredith N Braskie, Susan M Landau, William J Jagust, the U.S. POINTER Study Group, the Alzheimer's Disease Neuroimaging Initiative |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |