Plasma ADRD biomarkers predict longitudinal declines in intra‐network functional brain connectivity, and baseline functional connectivity predicts longitudinal cognition
Heather E Dark, Andrea T Shafer, Jenifer Cordon, Yang An, Alexandria Lewis, Abhay Moghekar, Bennett A. Landman, Susan M. Resnick, Keenan A. Walker · 2025
Read Plasma ADRD biomarkers predict longitudinal declines in intra‐network functional brain connectivity, and baseline functional connectivity predicts longitudinal cognition by Heather E Dark, Andrea T Shafer, Jenifer Cordon, Yang An, Alexandria Lewis, Abhay Moghekar, Bennett A. Landman, Susan M. Resnick, Keenan A. Walker (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715868.txt.
Description
Heather E Dark and co-authors test whether blood markers of Alzheimer's disease predict how brain networks weaken over time, in a 2025 study. The work uses data from the Baltimore Longitudinal Study of Aging, whose volunteers return for repeat scans and tests. The team focused on links within seven large brain networks that support memory and thought.
The analysis covered 490 adults without thinking problems, followed for about four years on average. Higher blood levels of markers for cell injury and stress went with faster loss of links inside several networks. The pattern differed between people with and without amyloid in the brain. Stronger network links at the start also predicted better thinking later. Blood tests may thus flag brain change years before symptoms.
Catalog record
| CREATOR | Heather E Dark, Andrea T Shafer, Jenifer Cordon, Yang An, Alexandria Lewis, Abhay Moghekar, Bennett A. Landman, Susan M. Resnick, Keenan A. Walker |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |