Development of blood biomarker for Alzheimer disease using neuron‐derived extracellular vesicles
Takashi Kudo, Shoshin Akamine · 2025
Read Development of blood biomarker for Alzheimer disease using neuron‐derived extracellular vesicles by Takashi Kudo, Shoshin Akamine (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715867.txt.
Description
Takashi Kudo and Shoshin Akamine develop a blood test route for Alzheimer's disease based on vesicles shed by neurons. Tiny extracellular vesicles from the brain drift into the blood, and catching the neuron-born ones could give a window on disease. The team first grew neurons from stem cells to learn the surface marks of their vesicles.
In their 2025 paper, one mark, APLP1, stood out as neuron-specific. Blood plasma held vesicles that carried it, sorted first by size and then pulled out with an antibody. Vesicles from patients with Alzheimer's disease were read with a digital assay. Their tau levels tracked the known markers in spinal fluid, a sign the blood route may serve as a biomarker.
Catalog record
| CREATOR | Takashi Kudo, Shoshin Akamine |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 1 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |