Genetic contribution to the sex differences of tau pathologies in Alzheimer’s disease –APOE and beyond
Yi‐Ting Wang, Joseph Therriault, Nesrine Rahmouni, Arthur C. Macedo, Stijn Servaes, Jaime Fernandez Arias, Sulantha Mathotaarachchi, Jenna Stevenson, Serge Gauthier, Pedro Rosa‐Neto, for the Alzheimer’s Disease Neuroimaging Initiative · 2025
Read Genetic contribution to the sex differences of tau pathologies in Alzheimer’s disease –APOE and beyond by Yi‐Ting Wang, Joseph Therriault, Nesrine Rahmouni, Arthur C. Macedo, Stijn Servaes, Jaime Fernandez Arias, Sulantha Mathotaarachchi, Jenna Stevenson, Serge Gauthier, Pedro Rosa‐Neto, for the Alzheimer’s Disease Neuroimaging Initiative (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715859.txt.
Description
Yi-Ting Wang and co-authors ask which genes drive sex gaps in tau build-up in Alzheimer disease. Their twenty twenty-five study uses two cohorts with brain scans and gene data. Women carry more tau than men at the same disease stage, a gap with real care stakes.
The APOE gene is the known giant here, and its effect may bend by sex. The team also built a polygenic hazard score from thirty-one risk variants. Scans for amyloid and tau let them split gene effects by pathology type. Three hundred fifty-nine and two hundred eighty-three patients fed the two cohorts. Beyond APOE, the gene map for the sex gap is the open frontier.
Catalog record
| CREATOR | Yi‐Ting Wang, Joseph Therriault, Nesrine Rahmouni, Arthur C. Macedo, Stijn Servaes, Jaime Fernandez Arias, Sulantha Mathotaarachchi, Jenna Stevenson, Serge Gauthier, Pedro Rosa‐Neto, for the Alzheimer’s Disease Neuroimaging Initiative |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |