Lower brain‐derived neurotrophic factor levels and hippocampal subfield volumes are associated with high diabetes risk in later life
Jennifer Hanna Al‐Shaikh, Olivia R Ghosh‐Swaby, Ali R Khan, Jane Thornton, Timothy J Bussey, Lisa M Saksida, Teresa Liu‐Ambrose, Lindsay S Nagamatsu · 2025
Read Lower brain‐derived neurotrophic factor levels and hippocampal subfield volumes are associated with high diabetes risk in later life by Jennifer Hanna Al‐Shaikh, Olivia R Ghosh‐Swaby, Ali R Khan, Jane Thornton, Timothy J Bussey, Lisa M Saksida, Teresa Liu‐Ambrose, Lindsay S Nagamatsu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715853.txt.
Description
Jennifer Hanna Al-Shaikh and co-authors link diabetes risk to a brain growth factor and to the size of memory zones, in a study from 2025. The factor, BDNF, helps new nerve cells grow in the hippocampus, the brain's memory hub. Both low BDNF and a shrunken hub show up in diabetes and in dementia.
Sixty adults aged 60 to 80, all at risk for diabetes, gave blood and had brain scans. Risk was scored from blood sugar, weight, and a form. Higher risk went with lower BDNF and with smaller zones inside the hippocampus. BDNF scores foresaw zone size in the dentate gyrus, a rare zone where new cells still form in adults. The team urges steps to block the slide from sugar risk to brain loss.
Catalog record
| CREATOR | Jennifer Hanna Al‐Shaikh, Olivia R Ghosh‐Swaby, Ali R Khan, Jane Thornton, Timothy J Bussey, Lisa M Saksida, Teresa Liu‐Ambrose, Lindsay S Nagamatsu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |