Cerebrovascular and Metabolic Alterations in a Mouse Model of Familial Alzheimer’s Disease Carrying the Notch3 C456R Mutation
Leila Letica, Sang‐Ho Choi, Lauren R Dubberley, Diego Szczupak, Jung Eun Park, David J Schaeffer, Afonso C Silva · 2025
Read Cerebrovascular and Metabolic Alterations in a Mouse Model of Familial Alzheimer’s Disease Carrying the Notch3 C456R Mutation by Leila Letica, Sang‐Ho Choi, Lauren R Dubberley, Diego Szczupak, Jung Eun Park, David J Schaeffer, Afonso C Silva (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715849.txt.
Description
Leila Letica and six co-authors bred a mouse that carries both inherited Alzheimer's traits and a vessel disease gene, in a 2025 study. Small vessel disease scars the aging brain with tiny strokes and bleeds, and it often mixes with Alzheimer's disease. The team asked whether the two pathologies add up or amplify each other in the brain's sugar use.
They crossed a standard Alzheimer's mouse with a mouse carrying a Notch3 mutation that causes the vessel disease. Awake mice got a sugar tracer, and scans read how much each brain area took up. Whole-brain uptake ran lower in all three mutant lines than in normal mice at every age. The paper sets up the double model as a tool for tracing how vessel and amyloid damage interact over time.
Catalog record
| CREATOR | Leila Letica, Sang‐Ho Choi, Lauren R Dubberley, Diego Szczupak, Jung Eun Park, David J Schaeffer, Afonso C Silva |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |