Spatial and sex‐specific hippocampal proteomic analysis of an early Alzheimer’s disease mouse model using MALDI‐imaging
Ana Contreras, Raquel Jimenez‐Herrera, Souhail Djebari, Jaime Mulero‐Franco, Juan D Navarro‐López, Lydia Jimenez‐Diaz · 2025
Read Spatial and sex‐specific hippocampal proteomic analysis of an early Alzheimer’s disease mouse model using MALDI‐imaging by Ana Contreras, Raquel Jimenez‐Herrera, Souhail Djebari, Jaime Mulero‐Franco, Juan D Navarro‐López, Lydia Jimenez‐Diaz (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715846.txt.
Description
Ana Contreras and five co-authors map protein changes in the hippocampus of mice given a dose of amyloid, the protein that builds up early in Alzheimer's disease, in this 2025 study. The lab had earlier shown that the dose weakens memory within an hour. What they did not know was which proteins shift inside the small subfields of the hippocampus, or whether males and females differ.
The team tested memory in sixteen mice, then used an imaging method that reads proteins directly from thin tissue slices. More than six hundred protein pieces were detected across the samples. Several differed between mice given amyloid and those given a plain solution. Pinpointing those proteins could reveal how amyloid first disrupts the memory circuits of the brain.
Catalog record
| CREATOR | Ana Contreras, Raquel Jimenez‐Herrera, Souhail Djebari, Jaime Mulero‐Franco, Juan D Navarro‐López, Lydia Jimenez‐Diaz |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |