Investigating Spatial Characteristics of Brain Atrophy in Alzheimer’s and LATE neuropathology
Khalid Saifullah, Abdur Raquib Ridwan, David A Bennett, Julie A Schneider, Konstantinos Arfanakis · 2025
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Description
Khalid Saifullah and four co-authors study brain shrinkage patterns tied to two diseases of old age in a 2025 paper. Alzheimer change and a second change, tied to a protein called TDP-43, often occur together in the same brain. The second can only be found after death, which blurs what each one does.
The team scanned single brain halves from 912 older adults after death and matched the scans with tissue checks. Shape-based measures let them map where tissue had thinned for each disease. The maps apart can help future scans sort the two apart in life, since each leaves its own pattern of loss.
Catalog record
| CREATOR | Khalid Saifullah, Abdur Raquib Ridwan, David A Bennett, Julie A Schneider, Konstantinos Arfanakis |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |