Associations Between Sex‐ and APOE‐Specific Transcriptomic Signatures in Alzheimer's Disease and Imaging‐Derived Phenotypes: An AZ‐ADRC‐Research Education Scholars Team Science Project
Adam C Raikes, Francesca Vitali, Gerson D Hernandez, Fei Yin · 2025
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Description
Adam C Raikes and three co-authors link gene activity patterns in the brain to scan based measures of Alzheimer's damage, in this 2025 team science paper. Risk for the late onset form of the disease depends in part on sex and on which version of the APOE gene a person carries. The group's earlier work found gene signatures that differ by both factors.
The team used brain tissue gene data from 369 donors and scan data from more than a thousand people in the same study. They compared cortex thickness and deep brain volumes between patients and controls within each sex and gene group. Where those gene signatures ran high, patients tended to show thinner cortex in matching regions. In gene carriers, signature levels also tracked with deep brain volumes. The work ties molecular patterns to visible brain change.
Catalog record
| CREATOR | Adam C Raikes, Francesca Vitali, Gerson D Hernandez, Fei Yin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |