Addressing the gaps of the functional neuroimaging in young APOEe4 carriers: A systematic review and Graph Theoretical analysis of brain connectivity
Ludmila Kucikova, Adam Brass, Xing Xiong, Jianmin Zeng, Craig Ritchie, Graciela Muniz‐Terrera, John T O'Brien, Li Su · 2025
Read Addressing the gaps of the functional neuroimaging in young APOEe4 carriers: A systematic review and Graph Theoretical analysis of brain connectivity by Ludmila Kucikova, Adam Brass, Xing Xiong, Jianmin Zeng, Craig Ritchie, Graciela Muniz‐Terrera, John T O'Brien, Li Su (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715826.txt.
Description
Ludmila Kucikova and co-authors study a gene risk for Alzheimer disease in a 2025 paper. One gene form, APOEe4, is the strongest known genetic risk for the common form of the disease. How it shapes brain function in young adults, long before symptoms, was the focus here.
A review of imaging studies found steady shifts in brain activity and links among carriers. The team then ran a graph analysis on resting brain networks of young adults aged seventeen to twenty-two. Two network measures were disrupted across several networks in carriers, though by unlike routes. The authors say the work is the first to show such wide network reshaping in young carriers.
Catalog record
| CREATOR | Ludmila Kucikova, Adam Brass, Xing Xiong, Jianmin Zeng, Craig Ritchie, Graciela Muniz‐Terrera, John T O'Brien, Li Su |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |