In‐Vivo Characterization of Blood‐Brain Barrier Permeability in Cognitively Normal APOE e4 Carriers and Non‐Carriers
Seraphina K. Solders, Qian Shen, Charlotte S. Rivera, Sarah Banks, Emilie T. Reas · 2025
Read In‐Vivo Characterization of Blood‐Brain Barrier Permeability in Cognitively Normal APOE e4 Carriers and Non‐Carriers by Seraphina K. Solders, Qian Shen, Charlotte S. Rivera, Sarah Banks, Emilie T. Reas (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715818.txt.
Description
Seraphina Solders and four co-authors scan the whole brain for blood-brain barrier leaks in healthy people who carry Alzheimer's risk. Barrier breakdown is tied to the disease, and APOE e4 carriers show leakier barriers, but past work stared only at known weak spots. Dynamic contrast MRI measured permeability in 34 cognitively normal older adults, mean age 76.6 years, split evenly by e4 status.
Values came from a standard cortical atlas, averaged across hemispheres. Carriers showed higher permeability in the reported regions. Models weighed age, sex, and their interplay with gene status. The work maps early vascular change before any symptoms.
Catalog record
| CREATOR | Seraphina K. Solders, Qian Shen, Charlotte S. Rivera, Sarah Banks, Emilie T. Reas |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |