Wnt/pathway, APP processing and telomere shortening in Down syndrome adults
Augusto Magno Tranquezi Cordeiro, Jessyka Maria de França Bram, Leda Leme Talib, Orestes Vicente Forlenza, Lillian Fernandes · 2025
Read Wnt/pathway, APP processing and telomere shortening in Down syndrome adults by Augusto Magno Tranquezi Cordeiro, Jessyka Maria de França Bram, Leda Leme Talib, Orestes Vicente Forlenza, Lillian Fernandes (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715816.txt.
Description
Augusto Magno Tranquezi Cordeiro and four co-authors probe three linked processes in adults with Down syndrome. Their 2025 study starts from shared ground between Down syndrome and Alzheimer's disease: both involve amyloid buildup and early aging. The team measured a signaling pathway called Wnt, the cutting of the amyloid precursor protein, and the length of telomeres, the caps that protect chromosome ends.
Blood and platelet samples came from fifty-five adults with Down syndrome and eighty without. The Down syndrome group showed more of the amyloid fragment Aβ40 and more of two precursor fragments, signs of unbalanced processing that could feed amyloid clumping. A key Wnt protein also ran higher, while telomeres ran shorter, matching the faster aging seen in the condition. The authors suggest the raised Wnt signal may be the body's attempt to offset the telomere loss, and call the pattern a lead for further study.
Catalog record
| CREATOR | Augusto Magno Tranquezi Cordeiro, Jessyka Maria de França Bram, Leda Leme Talib, Orestes Vicente Forlenza, Lillian Fernandes |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |