Investigating the role of gut microbiome in associations between fast food consumption and cerebrospinal fluid biomarkers of Alzheimer's disease in a cognitively unimpaired cohort
Darby Peter, Margo B. Heston, Qilin Hong, Puja Agarwal, Tyler K. Ulland, Sterling C. Johnson, Sanjay Asthana, Rob Knight, Rima Kaddurah‐Daouk, Henrik Zetterberg, Kaj Blennow, Federico E. Rey, Barbara B. Bendlin · 2025
Read Investigating the role of gut microbiome in associations between fast food consumption and cerebrospinal fluid biomarkers of Alzheimer's disease in a cognitively unimpaired cohort by Darby Peter, Margo B. Heston, Qilin Hong, Puja Agarwal, Tyler K. Ulland, Sterling C. Johnson, Sanjay Asthana, Rob Knight, Rima Kaddurah‐Daouk, Henrik Zetterberg, Kaj Blennow, Federico E. Rey, Barbara B. Bendlin (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715813.txt.
Description
Darby Peter and co-authors (2025) ask whether gut microbes carry part of fast food's effect on the brain in Alzheimer's disease. Western diets track with higher dementia risk. They also reshape the gut microbes, which talk to the brain through immune and metabolic channels. The missing link is mediation: do microbes sit on the causal path? The cohort here is cognitively healthy, so any signal precedes symptoms. The team measured fast food intake, gut microbe profiles from stool, and spinal fluid markers of Alzheimer's processes, neuron injury, and glial activation.
A mediation analysis then asks how much of the diet-to-marker link runs through the microbes. The author list spans nutrition, microbe science, and the major Alzheimer's marker laboratories, matching the question's shape. A proven microbial pathway would point to interventions, diet change, or microbial therapy, that could interrupt damage years before memory fails.
Catalog record
| CREATOR | Darby Peter, Margo B. Heston, Qilin Hong, Puja Agarwal, Tyler K. Ulland, Sterling C. Johnson, Sanjay Asthana, Rob Knight, Rima Kaddurah‐Daouk, Henrik Zetterberg, Kaj Blennow, Federico E. Rey, Barbara B. Bendlin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |