Characterizing brain structures associated with plasma neurofilament light chain among older adults: variations by sex and APOE gene
Yi Dong, Lin Song, Tingting Hou, Yuanjing Li, yongxiang wang, Yifeng Du, Chengxuan Qiu · 2025
Read Characterizing brain structures associated with plasma neurofilament light chain among older adults: variations by sex and APOE gene by Yi Dong, Lin Song, Tingting Hou, Yuanjing Li, yongxiang wang, Yifeng Du, Chengxuan Qiu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715808.txt.
Description
Yi Dong and co-authors link a blood marker of nerve damage to brain structure in older adults in rural China. The marker, neurofilament light chain, rises as nerve fibers break down. The 2025 study drew on 844 dementia-free adults aged sixty and up from the MIND-China cohort. Each gave blood in 2018 and had brain scans over the next two years.
Higher marker levels tracked more white matter damage and smaller grey matter in memory areas. Links were strongest for an Alzheimer's signature region. The ties showed mainly in men and in carriers of the APOE ε4 risk gene. The authors say the marker may flag early brain change in this population.
Catalog record
| CREATOR | Yi Dong, Lin Song, Tingting Hou, Yuanjing Li, yongxiang wang, Yifeng Du, Chengxuan Qiu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |