Evaluation of multiple ATN biomarker definitions for prediction of cognitive impairment
Tom Earnest, Braden Yang, Deydeep Kothapalli, Aristeidis Sotiras · 2025
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Description
Tom Earnest and three co-authors test how the choice of scoring method for three Alzheimer's markers changes predictions of thinking ability, in this 2025 study. The marker system, called ATN, grades amyloid, tau, and nerve damage. Labs score those markers in many ways: as simple yes or no calls, as grades, or as full numbers, and studies rarely compare the choices head to head.
The team used scans from 473 people in a national study and built prediction models under each scoring style. Adding any marker style beat age, sex, and gene data alone, with tau helping most. Fancier scoring, however, did not beat the simple yes or no approach once all three markers were in. The finding favors the simpler method for many uses.
Catalog record
| CREATOR | Tom Earnest, Braden Yang, Deydeep Kothapalli, Aristeidis Sotiras |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |