Natural amyloid deposition and neuroinflammation in both brain and eyeball of the old 5xFAD transgenic mouse using Integrated evaluation platform system combining amyloid PET/CT and Macro‐laser light sheet microscopy imaging with tissue clearing
Hye Joo Son · 2025
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Description
Hye Joo Son images Alzheimer's-linked change in both the brain and the eye of old gene-edited mice. The mice carry gene faults that build amyloid plaques, a hallmark of the disease. Son's 2025 study pairs standard PET scans with a laser-sheet microscope that reads whole cleared organs in 3D. Brains and eyeballs from disease mice and normal mice were stained for plaques and two immune cell kinds.
Disease brains held far more plaque than normal ones, and their eyeballs did too. Eye and brain plaque loads rose together closely. Signs of the two immune cell kinds also ran higher in disease brains. Son argues swelling stays active late in the disease, against the old script. The eye, easy to reach, may serve as an early window on the brain.
Catalog record
| CREATOR | Hye Joo Son |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |