Hypothalamic involvement and biomarker candidacy in Alzheimer’s disease in Down syndrome
Stephanie S G Brown, Shahid Zaman, John T O'Brien, ABC‐DS Consortium · 2025
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Description
Stephanie S G Brown, Shahid Zaman, and John T O'Brien, with a research consortium, study the hypothalamus in people with Down syndrome who develop Alzheimer's disease, in this 2025 paper. The hypothalamus is a small brain region that controls sleep, and poor sleep is an emerging risk factor for dementia. Scans rarely measure it well because of its size.
The team scanned 353 people with Down syndrome and 37 sibling controls. Relative to head size, the hypothalamus was smaller in those with mild impairment or dementia than in healthy peers, and smaller size went with worse thinking. One front lower subregion also shrank faster with age in those with the disease. The authors suggest the region could serve as a useful marker of decline.
Catalog record
| CREATOR | Stephanie S G Brown, Shahid Zaman, John T O'Brien, ABC‐DS Consortium |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |