Markers of Interstitial Fluid Dynamics from Diffusion MRI Reveal Association with Amyloid Deposition in Cognitively Normal Older Adults
Chang‐Le Chen, Hecheng Jin, Noah Schweitzer, Davneet S Minhas, Victor L Villemagne, Shaolin Yang, Howard J Aizenstein, Minjie Wu · 2025
Read Markers of Interstitial Fluid Dynamics from Diffusion MRI Reveal Association with Amyloid Deposition in Cognitively Normal Older Adults by Chang‐Le Chen, Hecheng Jin, Noah Schweitzer, Davneet S Minhas, Victor L Villemagne, Shaolin Yang, Howard J Aizenstein, Minjie Wu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715753.txt.
Description
Chang-Le Chen and seven co-authors test whether fluid flow in the spaces around brain vessels can signal early amyloid deposition. The flow, part of the glymphatic system, helps clear waste from the brain. Weak flow has been tied to Alzheimer's disease, but links with early markers in cognitively normal adults remain underexplored. Their 2025 study uses diffusion MRI to track water motion along perivascular spaces, summarized in the DTI-ALPS index.
The group held 40 cognitively normal older adults, each with both the diffusion scan and a PET scan for amyloid. The team also built an automated version of the index that finds the target region on its own. Both scores added clear power to models of amyloid load, and the automated score added a little more. Higher flow went with lower amyloid load. The team offers the index as a hopeful early sign of glymphatic function and risk.
Catalog record
| CREATOR | Chang‐Le Chen, Hecheng Jin, Noah Schweitzer, Davneet S Minhas, Victor L Villemagne, Shaolin Yang, Howard J Aizenstein, Minjie Wu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |