Cerebrospinal fluid proteomics identifies biomarkers for discriminating amyloid PET and tau PET stages
Zhibo Wang, Yuhan Chen, Jianping Jia · 2025
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Description
Zhibo Wang, Yuhan Chen, and Jianping Jia searched spinal fluid proteins for markers that stage Alzheimer's disease in a 2025 study. Brain scans stage the disease well but are costly and scarce. Fluid tests exist, yet they track late stages poorly.
The team studied 115 people with both spinal fluid protein reads, covering some six thousand proteins, and two kinds of brain scan. Protein sets tied to the plaque stage and to the tangle stage surfaced, mostly around sugar use and nerve support. Machine learning then picked a seventeen-protein panel that split the scan stages cleanly. Small subsets of two to thirteen proteins already separated key stages with high accuracy. The panel beat the standard fluid markers the team compared against.
Catalog record
| CREATOR | Zhibo Wang, Yuhan Chen, Jianping Jia |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |