Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer’s disease
Lyduine E Collij, Sophie E Mastenbroek, Niklas Mattsson‐Carlgren, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Rik Ossenkoppele, Oskar Hansson, the Alzheimer's Disease Neuroimaging Initiative · 2025
Read Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer’s disease by Lyduine E Collij, Sophie E Mastenbroek, Niklas Mattsson‐Carlgren, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Rik Ossenkoppele, Oskar Hansson, the Alzheimer's Disease Neuroimaging Initiative (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715727.txt.
Description
Lyduine Collij and co-authors asked in 2025 whether a second brain pathology, Lewy bodies, makes Alzheimer's disease run faster. The two often coexist in the same brain, and spotting the mixture could matter for prognosis and for trial design.
The study drew 795 people with mild impairment or dementia from a major aging cohort, all with spinal fluid tests for both diseases. About one in five carried both pathologies. That mixed group showed worse brain fuel use at the start and steeper decline in thinking over time than Alzheimer's alone, after accounting for age, sex, and starting state. Brain tissue checks in a subgroup backed the fluid based sorting. The authors urge routine Lewy testing in Alzheimer's workups.
Catalog record
| CREATOR | Lyduine E Collij, Sophie E Mastenbroek, Niklas Mattsson‐Carlgren, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Rik Ossenkoppele, Oskar Hansson, the Alzheimer's Disease Neuroimaging Initiative |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |