Linking the estimated time of onset of low locus coeruleus integrity to the estimated time of onset of elevated entorhinal tau
Heidi IL Jacobs, Tobey J Betthauser, Alex Becker, Joost M Riphagen, Kathryn V Papp, Julie C Price, Dorene M Rentz, Reisa A Sperling, Keith A Johnson · 2025
Read Linking the estimated time of onset of low locus coeruleus integrity to the estimated time of onset of elevated entorhinal tau by Heidi IL Jacobs, Tobey J Betthauser, Alex Becker, Joost M Riphagen, Kathryn V Papp, Julie C Price, Dorene M Rentz, Reisa A Sperling, Keith A Johnson (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715723.txt.
Description
Heidi Jacobs and co-authors estimate when a small brainstem hub starts to fail in aging, in work from 2025. The locus coeruleus helps wakefulness and memory and may falter early in Alzheimer disease. Timing its decline could open a window for prevention trials.
Data came from 101 adults in a Harvard aging study with repeated brain scans. A modeling method dated each person's onset of low hub integrity. Those dates were set against the onset of raised tau in a memory cortex. Thinking scores over time were tracked as well. Most participants also had amyloid scans at entry. Linked timing would place the hub early in the disease cascade.
Catalog record
| CREATOR | Heidi IL Jacobs, Tobey J Betthauser, Alex Becker, Joost M Riphagen, Kathryn V Papp, Julie C Price, Dorene M Rentz, Reisa A Sperling, Keith A Johnson |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |