PET imaging utility of a novel Aβ‐tracking PET radiotracer, [18F]FC119S in aged vervet monkeys
Bhuvanachandra Bhoopal, Brett M Frye, Avinash Bansode, Mack Miller, Naresh Damuka, Krishna Kumar Gollepalli, Richard A Barcus, Samuel N Lockhart, Courtney L Sutphen, Matthew J Jorgensen, Suzanne Craft, Thomas C Register, Christopher T Whitlow, Carol A Shively, Kiran K Solingapuram Sai · 2025
Read PET imaging utility of a novel Aβ‐tracking PET radiotracer, [18F]FC119S in aged vervet monkeys by Bhuvanachandra Bhoopal, Brett M Frye, Avinash Bansode, Mack Miller, Naresh Damuka, Krishna Kumar Gollepalli, Richard A Barcus, Samuel N Lockhart, Courtney L Sutphen, Matthew J Jorgensen, Suzanne Craft, Thomas C Register, Christopher T Whitlow, Carol A Shively, Kiran K Solingapuram Sai (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715719.txt.
Description
Bhuvanachandra Bhoopal and a large team test a new PET imaging tracer, [18F]FC119S, in aged vervet monkeys in 2025. The tracer binds to aggregates of amyloid-beta, a protein that builds up in the aging brain. Older vervets form such aggregates, but many of their binding sites are low-affinity sites that common tracers miss. A pilot clinical trial had already shown higher tracer uptake in Alzheimer's patients than in cognitively normal participants.
The team produced the tracer by a fully automated method, then scanned 14 monkeys aged 19 to 27 years. Uptake in key brain regions rose with age and fell as brain tissue shrank. One spinal fluid marker of harm tracked the scan values best of all the fluid markers checked. The team says the tracer behaves in monkeys much as it did in humans. That supports more study of early disease pathways.
Catalog record
| CREATOR | Bhuvanachandra Bhoopal, Brett M Frye, Avinash Bansode, Mack Miller, Naresh Damuka, Krishna Kumar Gollepalli, Richard A Barcus, Samuel N Lockhart, Courtney L Sutphen, Matthew J Jorgensen, Suzanne Craft, Thomas C Register, Christopher T Whitlow, Carol A Shively, Kiran K Solingapuram Sai |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |