Plasma biomarkers in a cohort of cases with dementia and in cognitively preserved nonagenarians
Estrella Gómez‐Tortosa, Pablo Agüero, Alicia Ruiz Gonzales, Sonia Wagner, Ignacio Mahillo, Andrea Ruiz, María José Sainz, Raquel Téllez, Lucía Cremades‐Jimeno, Pascual Sanchez‐Juan · 2025
Read Plasma biomarkers in a cohort of cases with dementia and in cognitively preserved nonagenarians by Estrella Gómez‐Tortosa, Pablo Agüero, Alicia Ruiz Gonzales, Sonia Wagner, Ignacio Mahillo, Andrea Ruiz, María José Sainz, Raquel Téllez, Lucía Cremades‐Jimeno, Pascual Sanchez‐Juan (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715718.txt.
Description
Estrella Gomez-Tortosa and co-authors test blood markers for dementia in a Spanish cohort, in a 2025 study. Blood tests that use ultra-sensitive assays could screen for Alzheimer disease and a second dementia type. The cohort held close to two hundred people: patients with each dementia, controls, and people in their nineties with intact thinking.
Markers of the core Alzheimer proteins split the groups as expected, and blood values tracked spinal fluid values. Two markers of nerve damage and brain inflammation were highest in the ninety-year-olds, even above dementia patients. One nerve marker best separated the two dementia types. The authors note a puzzle: people who kept sharp minds into their nineties still carried high damage and inflammation markers. They argue more work is needed before such blood tests can guide clinic choices alone.
Catalog record
| CREATOR | Estrella Gómez‐Tortosa, Pablo Agüero, Alicia Ruiz Gonzales, Sonia Wagner, Ignacio Mahillo, Andrea Ruiz, María José Sainz, Raquel Téllez, Lucía Cremades‐Jimeno, Pascual Sanchez‐Juan |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |