Longitudinal stability of extra‐cerebral off‐target binding in [F‐18]MK6240 PET images
Andrew K McVea, Alexandra H DiFilippo, Max McLachlan, Brecca Bettcher, Sterling C. Johnson, Tobey J. Betthauser, Bradley T. Christian · 2025
Read Longitudinal stability of extra‐cerebral off‐target binding in [F‐18]MK6240 PET images by Andrew K McVea, Alexandra H DiFilippo, Max McLachlan, Brecca Bettcher, Sterling C. Johnson, Tobey J. Betthauser, Bradley T. Christian (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715712.txt.
Description
Andrew McVea and six colleagues measured stray tracer binding in brain scans of Alzheimer's patients over time, in a 2025 paper. The tracer, MK6240, lights up tau tangles on PET scans. It also sticks to the membranes and sinuses around the brain, and that off-target glow can spill into nearby brain readings.
The cohort held nearly a thousand scans, with about two hundred people scanned twice, roughly two years apart. Off-target signal did not vary with age or disease markers. It ran higher in women and in carriers of a known risk gene. Between visits, the stray signal wobbled far more than true brain signal did, by over threefold in the comparison region. The authors warn this noise can bias tau measurements. Work to find its source and correct for it is ongoing, they report.
Catalog record
| CREATOR | Andrew K McVea, Alexandra H DiFilippo, Max McLachlan, Brecca Bettcher, Sterling C. Johnson, Tobey J. Betthauser, Bradley T. Christian |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |