Cognitive reserve, microstructural brain lesions, and cognitive function in dementia‐free adults in UK Biobank
Xiaolei Han, Xin Huang, Yifeng Du, Chengxuan Qiu, yongxiang wang · 2025
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Description
Xiaolei Han and co-authors ask whether cognitive reserve can blunt the effect of microstructural brain lesions on cognition in dementia-free adults. Their 2025 study uses the UK Biobank, a large health resource in Britain. Reserve was built from education, occupation, physical activity, and social activity. The lesions were read from diffusion MRI scans that track water motion in white matter, the wiring of the brain.
The sample held 26,490 adults in the imaging part of the project. Lesion markers such as freer, more spread-out water motion went with slower processing speed, weaker attention, and weaker executive function. In the split by reserve, some lesion links with reasoning and memory appeared only in the low-reserve group. The authors read this as evidence that high reserve can soften the cost of the lesions. They still note that the data are a snapshot of linked traits, not a trial.
Catalog record
| CREATOR | Xiaolei Han, Xin Huang, Yifeng Du, Chengxuan Qiu, yongxiang wang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |