Investigating the ATN (Amyloid, Tau, Neurodegeneration) framework in Alzheimer’s Disease and its causal genetic‐drivers using Digital‐Twins
Apoorva Bharthur Sanjay, Li Sun, Deepanshi Shokeen, Ole Isacson, So‐Youn Shin, Jeanne Latourelle · 2025
Read Investigating the ATN (Amyloid, Tau, Neurodegeneration) framework in Alzheimer’s Disease and its causal genetic‐drivers using Digital‐Twins by Apoorva Bharthur Sanjay, Li Sun, Deepanshi Shokeen, Ole Isacson, So‐Youn Shin, Jeanne Latourelle (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715707.txt.
Description
Apoorva Bharthur Sanjay and co-authors probe the amyloid-tau-neurodegeneration framework of Alzheimer's disease with computer-built digital twins, in a 2025 study. The three hallmarks define the disease's biology and guide drug development. Their twins are Bayesian network models reverse-engineered from a major cohort dataset, linking tens of thousands of variables from 317 subjects.
Simulated interventions on the twins estimated which factors cause which outcomes, and in what order the hallmarks unfold. The models recovered known patterns, such as spinal fluid measures driving later degeneration. The team also hunted gene drivers of each hallmark and tested how age changes their effects, using paired interventions.
Catalog record
| CREATOR | Apoorva Bharthur Sanjay, Li Sun, Deepanshi Shokeen, Ole Isacson, So‐Youn Shin, Jeanne Latourelle |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |