First GPR39‐imaging radiotracer to track zinc homeostasis in a rodent model of Alzheimer’s disease
Krishna Kumar Gollepalli, Bhuvanachandra Bhoopal, Naresh Damuka, Ivan Krizan, Mack Miller, JV Shanmukha Kumar, Nagaraju Bashetti, Christopher T Whitlow, Samuel N Lockhart, Pooja Jadiya, Kiran K Solingapuram Sai · 2025
Read First GPR39‐imaging radiotracer to track zinc homeostasis in a rodent model of Alzheimer’s disease by Krishna Kumar Gollepalli, Bhuvanachandra Bhoopal, Naresh Damuka, Ivan Krizan, Mack Miller, JV Shanmukha Kumar, Nagaraju Bashetti, Christopher T Whitlow, Samuel N Lockhart, Pooja Jadiya, Kiran K Solingapuram Sai (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11715704.txt.
Description
Krishna Kumar Gollepalli and co-authors report a first imaging tracer in a 2025 Alzheimer's study. The receptor GPR39 helps manage zinc in the brain, and when zinc handling slips it feeds several hallmarks of Alzheimer's disease, from oxidative stress to tau changes. A tracer that lights up GPR39 could guide drugs aimed at it.
The team built a carbon-11 labeled version of a GPR39-targeting compound chosen for brain entry and tight binding. In rodents they ran hour-long PET scans and follow-up tissue distribution checks. The abstract presents the tracer as the first able to track this zinc-linked receptor in a living brain.
Catalog record
| CREATOR | Krishna Kumar Gollepalli, Bhuvanachandra Bhoopal, Naresh Damuka, Ivan Krizan, Mack Miller, JV Shanmukha Kumar, Nagaraju Bashetti, Christopher T Whitlow, Samuel N Lockhart, Pooja Jadiya, Kiran K Solingapuram Sai |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |