Molecular biomarkers for Alzheimer’s disease and related dementias – improved methods to facilitate global studies
Henrik Zetterberg · 2025
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Description
Henrik Zetterberg reports new ways to measure blood biomarkers for Alzheimer's disease and related dementias, aimed at global studies. Recent tools can read markers in normal plasma and in dried plasma spots. A new method called NULISA was checked against the Simoa platform.
Proteins from dried spots kept at room temperature for weeks could still be read well. Markers such as P-tau217, neurofilament light and GFAP matched Simoa results closely, though spot levels were lower than in venous blood. NULISA was at least ten times as sensitive and could read three markers from one drop. Zetterberg notes that spot-specific reference limits are still needed.
Catalog record
| CREATOR | Henrik Zetterberg |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |